From quiescence to senescence
نویسندگان
چکیده
منابع مشابه
CDK4/6 inhibitor: from quiescence to senescence
The CDK4 and CDK6 kinases (CDK4/6) are the first cyclin dependent kinases to be activated and initiate transition through G1 phase of the cell cycle. In response to mitogenic growth factors, the CDK4/6 kinase together with one of three D-type cyclins (D1, D2, D3) initiates G1 progression by virtue of its capacity to phosphorylate the retinoblastoma protein (RB), a bona fide tumor suppressor and...
متن کاملElimination of Proliferating Cells Unmasks the Shift from Senescence to Quiescence Caused by Rapamycin
BACKGROUND Depending on cellular context, p53-inducing agents (such as nutlin-3a) cause different outcomes including reversible quiescence and irreversible senescence. Inhibition of mTOR shifts the balance from senescence to quiescence. In cell lines with incomplete responses to p53, this shift may be difficult to document because of a high proportion of proliferating cells contaminating arrest...
متن کاملmTOR favors senescence over quiescence in p53-arrested cells
p53 tumor suppressor protein controls cell fate by inducing apoptosis or cell cycle arrest in response to cell stress [1]. Cell cycle arrest can be temporary (quiescent) or permanent (senescent) depending on p53 regulation [2,3]. Under normal conditions, p53 binds to MDM2, which transports the protein to the cytoplasm where it undergoes rapid proteosomal degradation. A class of chemotherapeutic...
متن کاملThe p53 inducing drug dosage may determine quiescence or senescence
protein p53 regulates the fate of cells [1]. Blagosklonny and his colleagues [2], and others [3] in a series of studies have been using the non-genotoxic p53 activator, Nutlin-3a, to understand further how p53 induction can determine whether cells arrest die or senesce. In earlier work the p53 dependence of cell cycle arrest, apoptosis, autophagy and senescence has been unequivocally demonstrat...
متن کاملP53 levels govern the choice between senescence and quiescence
Activation of p53 plays a pivotal role in protecting against the survival and systemic spread of potential tumour cells. It can also influence the aging process and, reciprocally, p53 function has been reported to decline with age [1,2]. The biological outcome of inducing p53 is of great topical interest, with much focus on the numerous factors that lead to growth arrest or programmed cell deat...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2014
ISSN: 1538-4101,1551-4005
DOI: 10.4161/15384101.2014.980696